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Obesity and Overeating: Research Fundamentals

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Obesity and Overeating: Research Fundamentals

4.85 90,587 ratings · 8,863 reviews
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Overview: With the increasing worldwide incidence of obesity and the resulting increase in metabolic disorders such as diabetes, cardiovascular diseases and some cancers, an understanding of the multitude of factors that contribute to obesity is crucial for researchers to develop more effective treatments. This collection of overviews and protocols provides the reader with an introduction to the major features of obesity research, including the interplay between energy balance, hormones and neurobiological networks. An overview is provided which describes the animal models of obesity most commonly utilized in research. A standardized laboratory protocol for producing diet?]induced obesity (DIO) in both mouse and rat is provided as are protocols that describe how diet formulation can be modified to generate mouse models of human metabolic pathologies. Protocols are also provided for testing the effects of dietary manipulations, caloric restriction and potential therapeutics.This e-book -- a curated collection from eLS, WIREs, and Current Protocols -- offers a fantastic introduction to the field of obesity research for students or interdisciplinary collaborators.Table of Contents:IntroductionEnergy Balance, Obesity and Type 2 Diabetes"eLS"M. Daniel LaneNeurobiology of Overeating"eLS"Eric Stice and Kyle S. BurgerPrimary Hormones and Receptors Studied in Obesity ResearchObesity Hormones in Health and Disease"eLS"Emrah CaylakCentral Dopaminergic Circuitry Controlling Food Intake and Reward: Implications for the Regulation of Obesity"WIREs Systems Biology and Medicine"Zivjena Vuceti and Teresa M. ReyesProtocolsOverview of Animal Models of Obesity"Current Protocols in Pharmacology"Thomas A. Lutz and Stephen C. WoodsDiet-Induced Models of Obesity (DIO) in Rodents"Current Protocols in Neuroscience"Didier Bagnol, Hussien Al-Shamma, Dominic Behan, Kevin Whelan and Andrew J. GrottickDietary Manipulation of Mouse Metabolism"Current Protocols in Molecular Biology"Jerome N. Feige, Marie Lagouge and Johan Auwerx

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After spending years working in the corporate world, John Wiley & Sons finally decided to pursue a lifelong passion for writing. They currently reside in a quiet suburb where they spend most of their time outlining new stories, reading extensively, and occasionally attempting to bake.

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Donna Carter
Donna Carter June 08, 2025
A highly sophisticated read. It held my rapt attention, even when certain twists were telegraphed. A very distinguished novel.
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Exceeded all my expectations. I adored how the story unfolded. It kept me captivated without sacrificing elegance. A true literary gem.
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A highly sophisticated read. It held my rapt attention, even when certain twists were telegraphed. Quite impressive overall.
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A profoundly satisfying read. The author orchestrated a breathtaking finale. Truly a work of art. Worth every moment spent reading.
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Such a rich narrative. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece.
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Exceeded all my expectations. The author orchestrated a breathtaking finale. Truly a work of art. A true literary gem.
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Such a rich narrative. The author orchestrated a breathtaking finale. Truly a work of art. Worth every moment spent reading.
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I thoroughly enjoyed the elegance of it. A brilliant concept executed with flair. Just a few pacing choices I would change. Quite impressive overall.
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Masterpiece from start to finish. I became deeply invested in the protagonist's journey. A masterclass in storytelling. Worth every moment spent reading.
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Honestly one of the most premium reading experiences lately. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. I will undoubtedly revisit this masterpiece.
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Absolutely brilliant. I adored how the story unfolded. It kept me captivated without sacrificing elegance. An effortless 5 stars.
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I was completely blown away. I adored how the story unfolded. It kept me captivated without sacrificing elegance. A true literary gem.
Susan Anderson
Susan Anderson September 04, 2024
Honestly one of the most premium reading experiences lately. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An effortless 5 stars.
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Such a rich narrative. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. I will undoubtedly revisit this masterpiece.
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Absolutely brilliant. The author orchestrated a breathtaking finale. Truly a work of art. Worth every moment spent reading.
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A very strong entry. A brilliant concept executed with flair. Just a few pacing choices I would change. A very distinguished novel.
Betty Carter
Betty Carter September 29, 2024
I was completely blown away. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. An effortless 5 stars.
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Susan Reyes May 30, 2024
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Joshua Young
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A profoundly satisfying read. I became deeply invested in the protagonist's journey. A masterclass in storytelling. Worth every moment spent reading.
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Masterpiece from start to finish. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. I will undoubtedly revisit this masterpiece.
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Such a rich narrative. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. An effortless 5 stars.
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James Hall
James Hall July 28, 2024
Such a rich narrative. I adored how the story unfolded. It kept me captivated without sacrificing elegance. An absolute must-read for connoisseurs of the genre.
Susan Robinson
Susan Robinson July 28, 2024
I was completely blown away. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An effortless 5 stars.
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I was completely blown away. I adored how the story unfolded. It kept me captivated without sacrificing elegance. A true literary gem.
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Exceeded all my expectations. I adored how the story unfolded. It kept me captivated without sacrificing elegance. An effortless 5 stars.
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Honestly one of the most premium reading experiences lately. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. I will undoubtedly revisit this masterpiece.
George Brown
George Brown May 22, 2024
I was completely blown away. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece.
Rebecca White
Rebecca White October 12, 2024
Honestly one of the most premium reading experiences lately. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. An effortless 5 stars.
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I thoroughly enjoyed the elegance of it. The middle had a deliberate pace, but the climax was phenomenal. I would highly recommend this to discerning readers.
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I was completely blown away. The prose is exquisite. It’s accessible yet undeniably sophisticated. I will undoubtedly revisit this masterpiece.
Joseph Allen
Joseph Allen August 08, 2024
Honestly one of the most premium reading experiences lately. The author orchestrated a breathtaking finale. Truly a work of art. I will undoubtedly revisit this masterpiece.
Susan Martin
Susan Martin March 05, 2024
Took a moment to build, but the payoff was spectacular. A brilliant concept executed with flair. Just a few pacing choices I would change. I would highly recommend this to discerning readers.
Michelle Evans
Michelle Evans October 13, 2024
I was completely blown away. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece.
Joseph Hill
Joseph Hill February 18, 2025
Took a moment to build, but the payoff was spectacular. The protagonist was compelling, though some subplots felt slightly overshadowed. A very distinguished novel.
Matthew Martinez
Matthew Martinez August 23, 2024
Such a rich narrative. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. I am now a lifelong fan of this author.
David Scott
David Scott July 28, 2025
I thoroughly enjoyed the elegance of it. The protagonist was compelling, though some subplots felt slightly overshadowed. I would highly recommend this to discerning readers.
Dorothy Taylor
Dorothy Taylor September 25, 2024
A decent, if standard, experience. The tempo was somewhat languid, and I found my mind wandering. Not poor, simply average. Suitable if your reading queue is empty.
Robert Lee
Robert Lee September 08, 2025
I find myself somewhat conflicted. The prose was competent, yet the characters lacked the depth I usually seek. Unlikely to reread, but a reasonable expenditure of time.
Anthony Carter
Anthony Carter July 06, 2025
Took a moment to build, but the payoff was spectacular. A brilliant concept executed with flair. Just a few pacing choices I would change. A solid 4 stars from me.
Michael Jackson
Michael Jackson November 04, 2025
Excellent, though slightly flawed. The protagonist was compelling, though some subplots felt slightly overshadowed. A solid 4 stars from me.
Dorothy Walker
Dorothy Walker July 31, 2024
Exceeded all my expectations. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. Worth every moment spent reading.
Sharon Johnson
Sharon Johnson June 02, 2024
Honestly one of the most premium reading experiences lately. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. Worth every moment spent reading.
Carol Lewis
Carol Lewis April 22, 2024
Excellent, though slightly flawed. It held my rapt attention, even when certain twists were telegraphed. Quite impressive overall.
Sandra Flores
Sandra Flores November 25, 2024
A profoundly satisfying read. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece.
Donald Roberts
Donald Roberts September 06, 2024
Excellent, though slightly flawed. It held my rapt attention, even when certain twists were telegraphed. A very distinguished novel.
Kenneth Clark
Kenneth Clark December 23, 2025
Excellent, though slightly flawed. A brilliant concept executed with flair. Just a few pacing choices I would change. A solid 4 stars from me.
Laura Wilson
Laura Wilson March 01, 2024
Excellent, though slightly flawed. The middle had a deliberate pace, but the climax was phenomenal. A very distinguished novel.
Brian Nguyen
Brian Nguyen October 21, 2024
Absolutely brilliant. The author orchestrated a breathtaking finale. Truly a work of art. Worth every moment spent reading.
Amanda Jackson
Amanda Jackson May 09, 2025
Exceeded all my expectations. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. An absolute must-read for connoisseurs of the genre.
Brian Taylor
Brian Taylor March 28, 2024
Exceeded all my expectations. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. Worth every moment spent reading.
Ashley Reyes
Ashley Reyes June 27, 2024
I thoroughly enjoyed the elegance of it. The middle had a deliberate pace, but the climax was phenomenal. A very distinguished novel.
Amanda Carter
Amanda Carter October 13, 2024
Honestly one of the most premium reading experiences lately. I adored how the story unfolded. It kept me captivated without sacrificing elegance. Worth every moment spent reading.
Thomas Jones
Thomas Jones October 18, 2025
I was completely blown away. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. I am now a lifelong fan of this author.
Paul Nguyen
Paul Nguyen November 27, 2024
I find myself somewhat conflicted. Certain acts were fascinating, while others felt like a slight endeavor to complete. Perhaps more aligned with a different audience's tastes.
Christopher Campbell
Christopher Campbell July 27, 2024
It was adequate. The prose was competent, yet the characters lacked the depth I usually seek. Perfectly average.
Mark Adams
Mark Adams March 18, 2024
Absolutely brilliant. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. I am now a lifelong fan of this author.
Edward Moore
Edward Moore April 07, 2024
A highly sophisticated read. Beautiful writing, though I craved slightly more depth in the lore. Still, undeniably engaging. A solid 4 stars from me.
Lisa Diaz
Lisa Diaz May 13, 2025
Masterpiece from start to finish. I adored how the story unfolded. It kept me captivated without sacrificing elegance. An effortless 5 stars.
Rebecca Robinson
Rebecca Robinson November 06, 2024
A very strong entry. It held my rapt attention, even when certain twists were telegraphed. A very distinguished novel.
Jessica Ramirez
Jessica Ramirez March 18, 2025
Excellent, though slightly flawed. A brilliant concept executed with flair. Just a few pacing choices I would change. I would highly recommend this to discerning readers.
John Edwards
John Edwards September 09, 2024
I was completely blown away. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An absolute must-read for connoisseurs of the genre.
Anthony Young
Anthony Young December 21, 2025
Honestly one of the most premium reading experiences lately. The author orchestrated a breathtaking finale. Truly a work of art. Worth every moment spent reading.
Barbara Martinez
Barbara Martinez September 17, 2025
Such a rich narrative. I adored how the story unfolded. It kept me captivated without sacrificing elegance. A true literary gem.
Michael Campbell
Michael Campbell May 07, 2025
A highly sophisticated read. The middle had a deliberate pace, but the climax was phenomenal. A wonderful companion for a quiet weekend.
Cynthia Lewis
Cynthia Lewis May 05, 2024
Exceeded all my expectations. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. A true literary gem.
David Scott
David Scott November 15, 2024
Honestly one of the most premium reading experiences lately. The author orchestrated a breathtaking finale. Truly a work of art. An effortless 5 stars.
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