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Sjoerdsma, Ann G.'s Starting with Serotonin: How a High-Rolling Father of Drug Discovery Repeatedly Beat the Odds 1st (first) edition by Sjoerdsma, Ann G. published by Improbable Books [Hardcover] (2008)

Penned By Ann Sjoerdsma
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Sjoerdsma, Ann G.'s Starting with Serotonin: How a High-Rolling Father of Drug Discovery Repeatedly Beat the Odds 1st (first) edition by Sjoerdsma, Ann G. published by Improbable Books [Hardcover] (2008)

Penned By Ann Sjoerdsma
4.85 40,114 Ratings
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Editor's Note:
When Albert Sjoerdsma, M.D., Ph.D., arrived at the National Institutes of Health in the early 1950s, hypertension still regularly debilitated and killed people. He resolved to change this. Sjoerdsma had read that, when given intravenously, serotonin dramatically elevated a person's blood pressure. Maybe, the young researcher reasoned, he could manipulate serotonin in the body, by blocking a key enzyme in its chemical "pathway," and bring blood pressure down. This was revolutionary thinking. Most drug discovery at the time was a matter of luck, not rational conception. And little was known about serotonin, a "garden-variety" neurotransmitter today, except that it played a role in blood clotting. For twenty years, Sjoerdsma explored wide-ranging, uncharted territory in his Experimental Therapeutics Branch of the National Heart Institute. Launched by his ground-breaking serotonin studies, he diagnosed and defined a cancer known as the carcinoid syndrome; established the mechanism of action of the first antidepressants, which originated in a major drug company's tuberculosis program; measured serotonin, dopamine, and other amines in bananas and other foods, discovered the antihypertensive, Aldomet, a former Top-10 drug; identified treatment for the skin scourge, scleroderma, and the unusual high-blood-pressure disorder, pheochromocytoma; probed the biochemical nature of rapid-eye movement sleep, and much, much more. Because of his inspired work at the NIH and the training he gave his young clinical associates--newly graduated physicians who later spread his research gospel to academia--the tough-talking and straight-shooting Sjoerdsma became known as the Father of Clinical Pharmacology. An advocate of designing drugs that work by inhibiting enzymes, Sjoerdsma went on to enjoy decades-long success as a worldwide leader in the pharmaceutical industry, eventually serving as president of the Merrell Dow Research Institute, headquartered in Cincinnati. With a talented cadre of scientists, the unpredictable innovator developed the first-ever rationally designed antiepileptic (Sabril), also used today to treat a devastating infantile spasm disorder, and the first-ever non-sedating antihistamine, Seldane, replaced in time by its metabolite, Allegra. His crowning glory was the first-ever 100-percent cure for deadly African sleeping sickness--a drug known simply as DFMO. Long before American eyes opened to Third World health tragedies, Sjoerdsma had a lab devoted to research on parasitic diseases, as well as more traditional cancer and heart disease programs. He also contributed to the early treatment of AIDS patients. Gifted at discovery, Al Sjoerdsma always practiced good science, "followed his nose," and optimized the experimental odds in his favor. The research that the Father of Clinical Pharmacology conducted--his brainstorming--still has relevance today in the era of gene-replacement therapy and "Big Pharma." "Starting with Serotonin" shows his prescription for scientific creative freedom and productivity in action--lead by lead by compelling lead.

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Released July 28, 2008
Identifier (ISBN) 132293584
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Ann Sjoerdsma
The Mind Behind the Work
Ann Sjoerdsma

Ann Sjoerdsma writes contemporary fiction and has always been fascinated by character-driven stories. They hold a degree in English Literature and previously worked as an editor before transitioning to writing their own books. Ann Sjoerdsma lives with their spouse and a very vocal rescue cat.

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"Masterpiece from start to finish. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. I will undoubtedly revisit this masterpiece."
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"Exceeded all my expectations. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece."
Michelle Clark
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"Took a moment to build, but the payoff was spectacular. The middle had a deliberate pace, but the climax was phenomenal. A very distinguished novel."
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"I was completely blown away. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. I am now a lifelong fan of this author."
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"Such a rich narrative. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. I will undoubtedly revisit this masterpiece."
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"A highly sophisticated read. The middle had a deliberate pace, but the climax was phenomenal. Quite impressive overall."
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"Exceeded all my expectations. I adored how the story unfolded. It kept me captivated without sacrificing elegance. I will undoubtedly revisit this masterpiece."
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"I was completely blown away. The author orchestrated a breathtaking finale. Truly a work of art. I am now a lifelong fan of this author."
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"A profoundly satisfying read. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece."
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"I thoroughly enjoyed the elegance of it. The middle had a deliberate pace, but the climax was phenomenal. A wonderful companion for a quiet weekend."
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"Exceeded all my expectations. The prose is exquisite. It’s accessible yet undeniably sophisticated. A true literary gem."
Susan Phillips
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"Absolutely brilliant. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. A true literary gem."
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Kimberly Harris
Kimberly Harris August 01, 2024
"I was completely blown away. The author orchestrated a breathtaking finale. Truly a work of art. An absolute must-read for connoisseurs of the genre."
John Garcia
John Garcia November 05, 2024
"Exceeded all my expectations. I became deeply invested in the protagonist's journey. A masterclass in storytelling. A true literary gem."
Edward Thompson
Edward Thompson October 08, 2024
"A profoundly satisfying read. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I am now a lifelong fan of this author."
Betty Thomas
Betty Thomas July 18, 2024
"A decent, if standard, experience. Certain acts were fascinating, while others felt like a slight endeavor to complete. Perfectly average."
Margaret Robinson
Margaret Robinson May 22, 2024
"Took a moment to build, but the payoff was spectacular. The protagonist was compelling, though some subplots felt slightly overshadowed. Quite impressive overall."
Melissa Collins
Melissa Collins February 24, 2025
"I thoroughly enjoyed the elegance of it. A brilliant concept executed with flair. Just a few pacing choices I would change. I would highly recommend this to discerning readers."
Sandra Johnson
Sandra Johnson November 20, 2025
"Exceeded all my expectations. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. Worth every moment spent reading."
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